eu efre logo

Science Publication by A. Dityatev

 

The CBBS congratulates Alexander Dityatev’s working group at the German Center for Neurodegenerative Diseases (DZNE) on the latest publication in Science about CPTX, a synthetic synaptic organizer protein, which restores glutamatergic neuronal circuits.

Summary:

Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory–inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to restore this balance are highly desirable. Here, we designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1. CPTX can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors and induced the formation of excitatory synapses both in vitro and in vivo. CPTX restored synaptic functions, motor coordination, spatial and contextual memories, and locomotion in mouse models for cerebellar ataxia, Alzheimer’s disease, and spinal cord injury, respectively. Thus, CPTX represents a prototype for structure-guided biologics that can efficiently repair or remodel neuronal circuits.

Summary of Science article.

Information about Alexanders Lab.

LECTURE SERIES mit Magdalena Sauvage

Am Dienstag, den 12. Januar 2021 findet um 16.00 Uhr, ein Zoom-Vortrag mit Professor Dr. Magdalena Sauvage statt.

Forschungsjournal GUERICKE`20 erschienen

Das CBBS hat schon einen Blick in das neue Forschungsjournal GUERICKE`20 geworfen.

Erfolgreiche Bewilligung des SFBs „Neuronale Ressourcen der Kognition“

Das CBBS gratuliert den CBBS-Mitgliedern Emrah Düzel und Michael Kreutz zum neuen SFB

Offene Stellen für Doktoranden und Postdocs gesucht?

Gefunden am Schwarzen Brett des CBBS-GP!

weitere Meldungen

weiterlesen... 

Mitglieder

Otto-von-Guericke-Universität Magdeburg

LIN Leibnizinstitut für Neurobiologie Magdeburg


Nachwuchsförderung

CBBS Graduierten Logo