NeuroNetwork 11
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Project title: Promoting memory by behavioral tagging: from cellular function towards application in humans Project leader: Elke Edelmann, Jorge Ricardo Bergado Acosta, Kerstin Krauel
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In our CBBS-NeuroNetwork, we focus on novelty exposure and novelty-related neurotransmitter-induced facilitation of learning and memory in animals and humans. This process is called “behavioral tagging” and is described to be important for learning and long-term memory. However the process of “behavioral tagging” is not yet fully determined and understood.
By applying a combined methodological approach, e.g., electrophysiology, pharmacology and behavior, we will investigate the underlying mechanisms and the time-dependency of “behavioral tagging" on cellular and systemic levels in animals and humans. We will focus on the action of dopamine and noradrenaline in the process of “behavioral tagging”, since these neurotransmitters are crucially involved in novelty processing in the brain. Additionally, we will investigate children and adolescents with attention deficit hyperactivity disorder (ADHS) who are impaired in memory formation due to a reduced availability of dopamine and noradrenaline.
With the help of our translational approach we will be able to develop strategies, which can facilitate learning in healthy individuals as well as in learning-disabled persons.
