LSA Fellows 3
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Project title: Mechanisms of presynaptic plasticity: alternative processing of Bassoon and interaction with c-terminal binding proteins (CtBPs) Projectleader: Dr. Marija Rankovic |
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The plasticity of synapses is a key element of brain functions including learning and memory processes. Multiple levels of plasticity have been identified during recent years, which are manifested and expressed on either side of the synapse. With my project I studied plasticity mechanisms that take place at the active zone of neurotransmitter release. In particular, the role of the various isoforms of the active zone scaffolding protein Bassoon in processes of Hebbian and homeostatic plasticity will be investigated, as recent studies performed in the context of the SFB 779 suggest an important role for these isoforms in plasticity processes.
