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NeuroNetwork 10


Project title: Optogenetic Read/Write Neuroprosthesis for Sensory Substitution

Project leader: Michael Lippert, Armin Dadgar


cCBBS Lippert 3 mini

Increasingly, high density electrode arrays implanted into the brain are being used to help patients with motor impairments. Signals from the electrodes can for example be used to control prostheses. Unfortunately, no such success has been reached for patients with sensory losses. While retina and cochlea implants are successful in patients with some remaining function of the effected organ, as soon as the damage is larger or localized in the brain itself, they fail. Currently there is no possibility to “write” information directly to the first stage of perception, the primary sensory cortex. One major reason for this problem is the unspecific nature of the commonly used electrical brain stimulation. In our project we want to overcome this challenge by using light and gene therapy instead of current to stimulate the brain. Recently, the advent of optogenetics—a technique that sensitizes brain cells to light—has created a completely new opportunity for highly specific and complex brain stimulation. By creating a high density matrix of 32 microscopic light emitters in combination with electrodes for recording, we will create a novel, light based neuroprosthesis. The high number and density of such emitters is made possible by our novel thin-film LEDs. We will then test the device in animals and investigate how to “recreate” discernible sensory percepts by optogenetic patterned light stimulation. The results of these experiments are the basis to translate the technique to human patients in the future.


Inventur in der Synapse

18.06.2019 - Forscher des LIN, der OVGU und des CBBS füllen die neu geschaffene Datenbank SynGO mit Informationen zu Proteinen in Synapsen weiterlesen...

Hörkortex verarbeitet nicht nur Töne

13.06.2019 - Forscher des LIN und des CBBS haben in einer Studie mit Langschwanzmakaken gezeigt, dass eine Assoziation zwischen akustischem Reiz und gelernter Reaktion im Hörkortex repräsentiert ist weiterlesen...

MCB BrainPlast International Conference Linking Molecules, Cells and Behavior II

09. - 11.09.2019 weiterlesen... 

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Otto-von-Guericke-Universität Magdeburg

LIN Leibniz Institute for Neurobiology Magdeburg

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